The immunohistochemical expression ki67 in polymorphous. Polymorphous lowgrade adenocarcinoma plga is a lowgrade malignant neoplasm usually arising in the minor salivary glands. Polymorphous low grade adenocarcinoma of minor salivary gland. It has previously been known as terminal duct carcinoma, lobular carcinoma, and lowgrade papillary adenocarcinoma. Histopathological spectrum of polymorphous lowgrade. Polymorphous low grade adenocarcinoma of the parotid in a teenager divya khosla1, shalini verma1, nitin gupta2, rajpals punia3, gurbir kaur1, awadheshk pandey1, kislay dimri1 abstract introduction. Polymorphous lowgrade adenocarcinoma primary central nervous system lymphoma primary effusion lymphoma. Metastases to locoregional lymph nodes occur in only 610% of cases. Most patients present with an asymptomatic mass in the hard palate. The immunohistochemical expression ki67 in polymorphous low grade adenocarcinoma of the salivary glands mustafa mohammed abdulhussain department of oral pathology, college of dentistry, almustansiriyah university, baghdad, iraq abstract background. Polymorphous lowgrade adenocarcinoma of salivary gland origin plga was initially described in 1984 and has since become an established clinicopathologic entity. Recently, two cases of plga with microscopically confirmed distant metastases have been reported. Polymorphous lowgrade adenocarcinoma is a distinct neoplasm of the. Karyotypic variability and evolutionary characteristics of a polymorphous low grade adenocarcinoma in the parotid gland.
Polymorphous lowgrade adenocarcinoma of the parotid. Polymorphous lowgrade adenocarcinoma located in the. Polymorphous lowgrade adenocarcinoma plga is one such tumor, misunderstood. Histologic transformation of polymorphous lowgrade. Polymorphous lowgrade adenocarcinoma is a malignant epithelial tumour with low metastatic rate and infiltrative growth pattern. It can also occur in minor salivary glands in the rest of the.
Pdf polymorphous low grade adenocarcinoma researchgate. What are synonyms for polymorphous lowgrade adenocarcinoma. Polymorphous lowgrade adenocarcinoma definition of. For language access assistance, contact the ncats public information officer. Polymorphous adenocarcinoma of the salivary glands university of. Polymorphous low grade adenocarcinoma plga is a rare salivary gland neoplasm with an indolent course. Polymorphous low grade adenocarcinoma has a consistent p63. Acinic cell adenocarcinoma mucoepidermoid carcinoma, low grade polymorphous lowgrade adenocarcinoma monomorphic adenoma gingival cyst of adult lymphoepithelial cyst epidermoiddermoid cyst thyroglossal tract cyst squamous cell carcinoma verrucous carcinoma lymphoma metastatic carcinoma melanoma sarcoma salivary gland adenocarcinoma. Request pdf polymorphous lowgrade adenocarcinoma polymorphous lowgrade adenocarcinoma plga is almost exclusively a minor salivary gland tumour and has been recognised since the early 1980s. It is important to differentiate plga from other salivary gland tumors with myoepithelial differentiation such as pleomorphic adenoma and adenoid cystic carcinoma. Treatment list for polymorphous lowgrade adenocarcinoma.
In such cases, it is critical to make a definite diagnosis as each of these tumors has an entirely different treatment protocol. The peripheral invasive component showed an indian file pattern of. Polymorphous lowgrade adenocarcinoma plga is a slowgrowing salivary gland malignancy with a nonaggressive behaviour. It is most commonly found in the palate the name of the tumor derives from the fact that. The term polymorphous lowgrade adenocarcinoma was later adopted in the 2nd who classification of 1991 and defined as a malignant epithelial tumour characterized by cytological uniformity, morphological diversity and a low metastatic potential. Management excision, postoperative radiation therapy. Salivary gland tumors are a relatively rare and morphologically diverse group of lesions. Always seek professional medical advice about any treatment or change in treatment plans. A 54yearold male presenting with a mass at the base of the tongue performed transoral laser microsurgery. Although most clinicians and pathologists will have encountered the more common benign neoplasms, few have the experience of all types of salivary cancers, which are best managed in specialist centers.
Pathology afip of plga arising within major salivary glands. Mixed tumor, polymorphous lowgrade adenocarcinoma and adenoid cystic carcinoma of the salivary gland. Polymorphous lowgrade adenocarcinoma december 5 th, 2008. A guide to clinical differential diagnosis of oral mucosal lesions continuing education brought to you by course author. Immunohistochemical pattern of pleomorphic adenoma. Polymorphous lowgrade adenocarcinoma plga and canalicular adenoma ca are relatively rare tumors of salivary gland. This tumor was recognized as a distinct entity in 1983 by freedman and lumerman and batsakis et al. Intracytoplasmic nuclear inclusions arrows, a feature found in some tumors. Polymorphous lowgrade adenocarconoma wexner medical center.
Pdf polymorphous lowgrade adenocarcinoma plga, is a rare. Polymorphous lowgrade adenocarcinomas are minor salivary gland neoplasms with a predilection for intraoral sites. Synonyms for polymorphous lowgrade adenocarcinoma in free thesaurus. Polymorphous definition of polymorphous by medical. Polymorphous lowgrade adenocarcinoma is a rare malignancy arising from the minor salivary glands in the aerodigestive system, most frequently the hard palate. Both lesions were recognized as independent entities in the latest scheme of classification of salivary gland tumors by the world health organization. This parotid epithelialmyoepithelial carcinoma shows a solid growth pattern with scattered tubules and mostly shows elongated nuclei with open chromatin and delicate nuclear membranes reminiscent of.
Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126. Polymorphous lowgrade adenocarcinoma has only rarely been reported in britain, but we believe it deserves wider recognition as a distinct clinicopathological entity and. The topic salivary gland polymorphous lowgrade adenocarcinoma you are seeking is a synonym, or alternative name, or is closely related to the medical condition polymorphous lowgrade adenocarcinoma of salivary gland. Treatments for polymorphous lowgrade adenocarcinoma. Polymorphous lowgrade adenocarcinoma of the tongue. Polymorphous low grade adenocarcinoma castle 1999 cancer. We report a case of plga arising from the parotid gland. This study is an analysis of the prevalence of polymorphous low grade adenocarcinoma plga in. Objectivethe aim of this case study was to describe an international case series of polymorphous lowgrade adenocarcinoma plga affecting the upper lip.
Polymorphous lowgrade adenocarcinoma genetic and rare. Paranasal sinuses are uncommon venues for polymorphous lowgrade adenocarcinoma. It has a varied microscopic architectural appearance, i. As the name implies, polymorphous lowgrade adenocarcinoma plga is a lowgrade neoplasm consisting of a uniform population of tumor cells that are arranged in a variety of architectural patterns polymorphous. Polymorphous lowgrade adenocarcinoma nord national. Polymorphous low grade adenocarcinoma is a rare malignant tumor of minor salivary glands. Common tumor of palate with infiltrative growth, multiple architectural growth patterns and cellular uniformity, first described in 1983 oral surg oral med oral pathol 1983.
If you have problems viewing pdf files, download the latest version of adobe reader. The list of signs and symptoms mentioned in various sources for polymorphous lowgrade adenocarcinoma includes the 5 symptoms listed below. Age and sex distribution polymorphous lowgrade adenocarcinoma of salivary gland has been recorded in teens, young, middleaged and elderly adults. Polymorphous low grade adenocarcinomas plgas are thought to be indolent tumours that are localised preferentially to the palate and affect the minor salivary glands almost exclusively. Polymorphous lowgrade adenocarcinoma plga is a lowgrade malignant epithelial tumor that is the second most common malignant neoplasm of minor salivary glands. We report a case of a 55 year old male who presented with an asymptomatic. Women are affected twice as frequently as men, and generally present in the fifth to sixth decade of life with a painless ihaoral mass. Comparative immunoprofile of polymorphous lowgrade. Ckit expression distinguishes salivary gland adenoid.
Polymorphous lowgrade adenocarcinoma of the salivary glands with transformation to highgrade carcinoma. Epidemiology represents 2 nd or 3 rd most common minor salivary gland malignancy 1726% 1st mucoepidermoid carcinoma rare in reported asian series female preponderance 2. Polymorphous low grade adenocarcinomas plga are minor salivary gland neoplasms with a predilection for intraoral sites. Polymorphous low grade adenocarcinoma lester dr thompson. Polymorphous lowgrade adenocarcinoma plga is a malignant epithelial tumor characterized by cytological uniformity, morphological diversity, an infiltrative growth pattern and low metastatic potential. Who gets polymorphous lowgrade adenocarcinoma of salivary gland. Polymorphous lowgrade adenocarcinoma lester dr thompson. Polymorphous lowgrade adenocarcinoma plga is a rare, asymptomatic, slowgrowing malignant salivary gland tumor. Polymorphous lowgrade adenocarcinoma plga is a rare tumor of the salivary glands that is limited, to a great extent, to the minor salivary glands and commonly, but not exclusively, localized in the palate of the mouth.
Clinical aspects usually the tumor is a painless mass, commonly in the palate, and often of long standing. Polymorphous lowgrade adenocarcinoma is a lowgrade and indolent neoplasm, with 1020% risk of local recurrence, and low risk for distant metastasis and death due to plga. Salivary gland polymorphous lowgrade adenocarcinoma. Polymorphous low grade adenocarcinoma of the hard palate. Polymorphous low grade adenocarcinoma plga is an indolent malignant tumor affecting the minor salivary gland almost exclusively. Polymorphous lowgrade adenocarcinoma of the tongue base. A carcinoma commonly misclassified as polymorphous lowgrade adenocarcinoma hematoxylineosin staining used in both parts of figure. Polymorphous lowgrade adenocarcinomas plga are distinctive salivary. The major salivary glands are the parotid glands at the side of the face, below the ears. Polymorphous lowgrade adenocarcinoma is a distinct neoplasm of the salivary gland composed of luminal and nonluminal tumor cells admixed in varying proportions.
In filtrating solid nests and cells growing in an adenoid cystic pattern arranged. Polymorphous low grade adenocarcinoma is a low grade adenocarcinoma involving predominantly minor salivary glands, particularly of the palate, where it represents the second most frequent malignant tumor. Selective immunohistochemical comparison of polymorphous lowgrade adenocarcinoma and adenoid cystic carcinoma. Rare cancers genetic and rare diseases information. Polymorphous low grade adenocarcinoma of the parotid in a. The treatment of choice is wide surgical resection, and the efficacy of radiotherapy has not been confirmed. Nonencapsulated uniform plump columnar cells with bland nuclei with diverse growth patterns tubular, cribriform, papillary, solid, fascicular, microcystic, single file, pseudoadenoid cystic without true lumens, strandlike, mixed. Polymorphous lowgrade adenocarcinoma of the nasopharynx. Polymorphous lowgrade adenocarcinomas are minor salivary gland. The present case showed predominant single file pattern of tumor cells. Owing to the indolent nature of plga and its relatively recent description, the full clinicopathologic spectrum of this entity has not been elucidated fully.
Polymorphous low grade adenocarcinoma with distant. Polymorphous low grade adenocarcinoma plga is a tumor of minor salivary glands that exhibits considerable morphologic overlap with adenoid cystic carcinoma and cellular pleomorphic adenoma, especially in small biopsy specimens. Here, we report a polymorphous lowgrade adenocarcinoma case of the maxillary sinus, a very rare. Figure 2 a image of polymorphous lowgrade adenocarcinoma comprising irregular. Its resemblance to lobular carcinoma of the breast had led to its earlier nomenclature of terminal duct carcinoma. A case report in a male 48 he had history of foul smelling discharge from the mouth. Polymorphous lowgrade adenocarcinoma of salivary gland origin plga was. Ce 110 a guide to clinical differential diagnosis of. Polymorphous lowgrade adenocarcinoma of salivary gland. Plga is predominantly found in females in their sixth to seventh decade, and it most commonly arises in the minor salivary glands, with more than half of cases involving the palate. The list of treatments mentioned in various sources for polymorphous lowgrade adenocarcinoma includes the following list.
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